Risk Factor Profiles in Patients with Different Clinical Manifestations of Venous Thromboembolism: A Focus on the Factor V Leiden Mutation
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چکیده
منابع مشابه
Risk factor profiles in patients with different clinical manifestations of venous thromboembolism: a focus on the factor V Leiden mutation.
BACKGROUND Patients with venous thromboembolic disease may present with different clinical manifestations. Factor V Leiden mutation leading to resistance to activated protein C is associated with a sevenfold increased risk for presenting with deep-vein thrombosis. It is not yet established whether carriers of the mutation have a similarly increased risk for manifesting with pulmonary embolism. ...
متن کاملFactor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
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BACKGROUND Recent findings have demonstrated a high frequency of activated protein C resistance in patients suffering from deep venous thrombosis (DVT). This abnormality has been related to a mutation in the factor V gene (at nucleotide position 1,691, guanine to adenine [G-->A] substitution). AIM To assess the frequency of the mutation in unselected inpatients with a proved DVT. To study the...
متن کاملThe association of factor V Leiden with various clinical patterns of venous thromboembolism-the factor V Leiden paradox.
BACKGROUND Factor V Leiden (FVL) supposedly carries relatively higher risk of deep vein thrombosis (DVT), compared to the risk of pulmonary embolism (PE). AIM To prove this paradox in a group of patients with various clinical presentation of venous thromboembolism (VTE). MATERIALS AND METHODS We retrospectively evaluated clinical pattern of VTE in patients who had been referred to vascular ...
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BACKGROUND AND OBJECTIVES In this retrospective, single center, cohort study we assessed the risk of pregnancy-related venous thromboembolism (VTE) in women belonging to a large number of families identified because of a symptomatic proband with single identified factor V Leiden mutation. DESIGN AND METHODS Female family members who had experienced at least one full-term pregnancy were enroll...
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ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 1996
ISSN: 0340-6245,2567-689X
DOI: 10.1055/s-0038-1650613